| Description : |
This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97.1 kDa |
| AA Sequence : |
MNYPGRGSPRSPEHNGRGGGGGAWE LGSDARPAFGGGVCCFEHLPGGDPD DGDVPLALLRGEPGLHLAPGTDDHN HHLALDPCLSDENYDFSSAESGSSL RYYSEGESGGGGSSLSLHPPQQPPL VPTNSGGGGATGGSPGERKRTRLGG PAARHRYEVVTELGPEEVRWFYKED KKTWKPFIGYDSLRIELAFRTLLQT TGARPQGGDRDGDHVCSPTGPASSS GEDDDEDRACGFCQSTTGHEPEMVE LVNIEPVCVRGGLYEVDVTQGECYP VYWNQADKIPVMRGQWFIDGTWQPL EEEESNLIEQEHLNCFRGQQMQENF DIEVSKSIDGKDAVHSFKLSRNHVD WHSVDEVYLYSDATTSKIARTVTQK LGFSKASSSGTRLHRGYVEEATLED KPSQTTHIVFVVHGIGQKMDQGRII KNTAMMREAARKIEERHFSNHATHV EFLPVEWRSKLTLDGDTVDSITPDK VRGLRDMLNSSAMDIMYYTSPLYRD ELVKGLQQELNRLYSLFCSRNPDFE EKGGKVSIVSHSLGCVITYDIMTGW NPVRLYEQLLQKEEELPDERWMSYE ERHLLDELYITKRRLKEIEERLHGL KASSMTQTPALKFKVENFFCMGSPL AVFLALRGIRPGNTGSQDHILPREI CNRLLNIFHPTDPVAYRLEPLILKR YSNISPVQIHWYNTSNPLPYEHMKP SFLNPAKEPTSVSENEGISTIPSPV TSPVLSRRHYGESITNIGKASILGA ASIGKGLGGMLFSRFGRSSTTQSSE TSKDSMEDEKKPVASPSATTVGTQT LPHSSSGFLDSALELDHRIDFELRE GLVESRYWSAVTSHTAYWSSLDVAL FLLTFMYKHEHDDDAKPNLDPITRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
