"DDR2" Related Products

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Recombinant Human DDR2 Protein, GST-His-tagged

Cat.No. : DDR2-2456H
Product Overview : Human DDR2 (NM_006182.2, 422 a.a. - 855 a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.
Description : Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Source : Insect Cells
Species : Human
Tag : GST-His
Form : Liquid
Bio-activity : 9 pmol/μg x min
Molecular Mass : 77.801 kDa
Applications : Functional Study
SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration : 0.102 μg/μL
Storage Buffer : In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Quality Control Testing: :

2 μg/lane SDS-PAGE Stained with Coomassie Blue

Result of activity analysis :

Gene Name : DDR2 discoidin domain receptor tyrosine kinase 2 [ Homo sapiens ]
Official Symbol : DDR2
Synonyms : DDR2; discoidin domain receptor tyrosine kinase 2; discoidin domain receptor family, member 2 , NTRKR3, TYRO10; discoidin domain-containing receptor 2; TKT; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2; MIG20a; NTRKR3; TYRO10;
Gene ID : 4921
mRNA Refseq : NM_001014796
Protein Refseq : NP_001014796
MIM : 191311
UniProt ID : Q16832

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