Recombinant Human DHDDS Protein (1-333 aa), GST-tagged

• Cat.No.: DHDDS-2138H
• Product Overview: Recombinant Human DHDDS Protein (1-333 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Full Length.

Specification

• Description: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 65.7 kDa
• Protein length: 1-333 aa
• AA Sequence: MSWIKEGELSLWERFCANIIKAGPM PKHIAFIMDGNRRYAKKCQVERQEG HSQGFNKLAETLRWCLNLGILEVTV YAFSIENFKRSKSEVDGLMDLARQK FSRLMEEKEKLQKHGVCIRVLGDLH LLPLDLQELIAQAVQATKNYNKCFL NVCFAYTSRHEISNAVREMAWGVEQ GLLDPSDISESLLDKCLYTNRSPHP DILIRTSGEVRLSDFLLWQTSHSCL VFQPVLWPEYTFWNLFEAILQFQMN HSVLQKARDMYAEERKRQQLERDQA TVTEQLLREGLQASGDAQLRRTRLH KLSARREERVQGFLQALELKRADWL ARLGTASA
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: DHDDS dehydrodolichyl diphosphate synthase [ Homo sapiens ]
• Official Symbol: DHDDS
• Synonyms: DHDDS; FLJ13102; HDS; dedol-PP synthase; CIT; CPT; RP59
• Gene ID: 79947
• mRNA Refseq: NM_001243564
• Protein Refseq: NP_001230493
• MIM: 608172
• UniProt ID: Q86SQ9