Recombinant Human DKK1 protein, His-Avi-tagged, Biotinylated
Cat.No. : | DKK1-490HB |
Product Overview : | Biotinylated Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a Avi, 6His tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Source : | HEK293 |
Species : | Human |
Tag : | His-Avi |
Form : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Molecular Mass : | 35-50kDa, reducing conditions. |
Protein length : | Thr32-His266 |
Endotoxin : | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | DKK1 dickkopf WNT signaling pathway inhibitor 1 [ Homo sapiens (human) ] |
Official Symbol : | DKK1 |
Synonyms : | Dickkopf-related protein 1; Dickkopf-1; Dkk-1 |
Gene ID : | 22943 |
mRNA Refseq : | NM_012242.4 |
Protein Refseq : | NP_036374.1 |
MIM : | 605189 |
UniProt ID : | O94907 |
Products Types
◆ Recombinant Protein | ||
DKK1-195H | Recombinant Human DKK1 Protein, Fc-tagged | +Inquiry |
Dkk1-197M | Recombinant Mouse Dkk1 Protein, His-tagged | +Inquiry |
DKK1-196H | Recombinant Human DKK1 Protein, Strep-tagged | +Inquiry |
DKK1-430D | Active Recombinant Human DKK1 Protein | +Inquiry |
DKK1-1267H | Acitve Recombinant Human DKK1 protein(Met2-His266), hFc-tagged | +Inquiry |
◆ Lysates | ||
DKK1-2622RCL | Recombinant Rhesus DKK1 cell lysate | +Inquiry |
DKK1-2983HCL | Recombinant Human DKK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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