"DMP1" Related Products

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Recombinant Human DMP1 Protein, MYC/DDK-tagged

Cat.No. : DMP1-2212H
Product Overview : Recombinant human DMP1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 52.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : DMP1 dentin matrix acidic phosphoprotein 1 [ Homo sapiens ]
Official Symbol : DMP1
Synonyms : ARHP; ARHR; DMP-1
Gene ID : 1758
mRNA Refseq : NM_001079911
Protein Refseq : NP_001073380
MIM : 600980
UniProt ID : Q13316

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