Recombinant Human DPP4 Protein

• Cat.No.: DPP4-793H
• Product Overview: Recombinant human DPP4 protein without tag was expressed in HEK293.

Specification

• Description: The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19.
• Source: HEK293
• Species: Human
• Form: Lyophilized
• Molecular Mass: 85.4 kDa
• Protein length: 766
• AA Sequence: MKTPWKVLLGLLGAAALVTIITVPV VLLNKGTDDATADSRKTYTLTDYLK NTYRLKLYSLRWISDHEYLYKQENN ILVFNAEYGNSSVFLENSTFDEFGH SINDYSISPDGQFILLEYNYVKQWR HSYTASYDIYDLNKRQLITEERIPN NTQWVTWSPVGHKLAYVWNNDIYVK IEPNLPSYRITWTGKEDIIYNGITD WVYEEEVFSAYSALWWSPNGTFLAY AQFNDTEVPLIEYSFYSDESLQYPK TVRVPYPKAGAVNPTVKFFVVNTDS LSSVTNATSIQITAPASMLIGDHYL CDVTWATQERISLQWLRRIQNYSVM DICDYDESSGRWNCLVARQHIEMST TGWVGRFRPSEPHFTLDGNSFYKII SNEEGYRHICYFQIDKKDCTFITKG TWEVIGIEALTSDYLYYISNEYKGM PGGRNLYKIQLSDYTKVTCLSCELN PERCQYYSVSFSKEAKYYQLRCSGP GLPLYTLHSSVNDKGLRVLEDNSAL DKMLQNVQMPSKKLDFIILNETKFW YQMILPPHFDKSKKYPLLLDVYAGP CSQKADTVFRLNWATYLASTENIIV ASFDGRGSGYQGDKIMHAINRRLGT FEVEDQIEAARQFSKMGFVDNKRIA IWGWSYGGYVTSMVLGSGSGVFKCG IAVAPVSRWEYYDSVYTERYMGLPT PEDNLDHYRNSTVMSRAENFKQVEY LLIHGTADDNVHFQQSAQISKALVD VGVDFQAMWYTDEDHGIASSTAHQH IYTHMSHFIKQCFSLP
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: DPP4 dipeptidyl-peptidase 4 [ Homo sapiens (human) ]
• Official Symbol: DPP4
• Synonyms: DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103
• Gene ID: 1803
• mRNA Refseq: NM_001935
• Protein Refseq: NP_001926
• MIM: 102720
• UniProt ID: P27487

Reviews

09/13/2019

Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

01/27/2019

By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

12/14/2016

Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

Q&As

How does DPP4 relate to diabetes?

DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

Are there any side effects associated with DPP4 inhibitors?

Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

What clinical applications does DPP4 have in managing type 2 diabetes?

Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

Can DPP4 inhibitors be used as a monotherapy for diabetes?

DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

How do DPP4 inhibitors differ from other diabetes medications?

DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.