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Recombinant Human DPP8 Protein (M1-I898), His tagged

Cat.No. : DPP8-0390H
Product Overview : Recombinant Human 8His-TEV-DPP 8(M1-I898 end) Protein was expressed in Insect cell.
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Description : Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid
Protein length : M1-I898
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name : DPP8 dipeptidyl-peptidase 8 [ Homo sapiens (human) ]
Official Symbol : DPP8
Synonyms : DPP8; dipeptidyl-peptidase 8; dipeptidylpeptidase 8; dipeptidyl peptidase 8; dipeptidyl peptidase IV related protein 1; dipeptidyl peptidase VIII; DP8; DPRP1; FLJ14920; FLJ20283; MGC26191; MSTP141; prolyl dipeptidase DPP8; DPRP-1; DPP VIII; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase IV-related protein-1;
Gene ID : 54878
mRNA Refseq : NM_017743
Protein Refseq : NP_060213
MIM : 606819
UniProt ID : Q6V1X1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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