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Recombinant Human DRD2 HEK293T cell lysate

Cat.No. : DRD2-21HL
Product Overview : Human DRD2 derived in Human HEK293T cell line.
  • Specification
  • Gene Information
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Description : This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
Source : Human HEK293T cell line
Species : Human
Tag : C-terminal Myc/DDK
Form : 1 vial of 100 ug gene specific transient over-expression cell lysate in RIPA buffer
1 vial of 100 ?g empty vector transfected control cell lysate in RIPA buffer
1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT)
Molecular Mass : 47.2 kDa
Storage : The lysate is shipped with dry ice. Upon receiving, store the sample at -20 centigrade. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles.
Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes.
Gene Name : DRD2 dopamine receptor D2 [ Homo sapiens ]
Official Symbol : DRD2
Synonyms : DRD2; dopamine receptor D2; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor; D2R; D2DR;
Gene ID : 1813
mRNA Refseq : NM_016574
Protein Refseq : NP_057658
MIM : 126450
UniProt ID : P14416
Chromosome Location : 11q22-q23
Pathway : Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;
Function : G-protein coupled receptor activity; dopamine binding; dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity, coupled via Gi/Go; drug binding; drug binding; ionotropic glutamate receptor binding; potassium channel regulator activity; protein binding; receptor activity; receptor binding; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What potential therapeutic applications arise from targeting DRD2 in neurological disorders? 05/30/2023

Targeting DRD2 could treat disorders like Parkinson's and schizophrenia.

How do genetic variations in DRD2 affect behavior? 03/20/2019

Genetic variations in DRD2 influence behavioral and mental health responses.

How does DRD2 contribute to motor control? 01/10/2019

It regulates motor control via dopamine pathways.

How does DRD2 interact with other dopamine receptors? 10/05/2018

DRD2 collaborates with other dopamine receptors in brain functions.

What is the primary role of DRD2 in neurotransmission? 03/26/2018

DRD2 modulates neurotransmitter signaling in the brain.

What role does DRD2 play in psychiatric disorders? 03/26/2018

DRD2 is key in psychiatric conditions, affecting mood and cognition.

What is the impact of altered DRD2 activity on addiction? 03/23/2017

Altered DRD2 activity is linked to addiction, affecting reward mechanisms.

Customer Reviews (3)

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Reviews
01/10/2019

    Integral to our research success, highly recommended.

    03/26/2018

      Efficiency at its best, a research cornerstone.

      03/26/2018

        Swift and accurate service, accelerates research timelines.

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