Recombinant Human DRD2 HEK293T cell lysate
Cat.No. : | DRD2-21HL |
Product Overview : | Human DRD2 derived in Human HEK293T cell line. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. |
Source : | Human HEK293T cell line |
Species : | Human |
Tag : | C-terminal Myc/DDK |
Form : | 1 vial of 100 ug gene specific transient over-expression cell lysate in RIPA buffer 1 vial of 100 ?g empty vector transfected control cell lysate in RIPA buffer 1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT) |
Molecular Mass : | 47.2 kDa |
Storage : | The lysate is shipped with dry ice. Upon receiving, store the sample at -20 centigrade. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles. Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes. |
Gene Name : | DRD2 dopamine receptor D2 [ Homo sapiens ] |
Official Symbol : | DRD2 |
Synonyms : | DRD2; dopamine receptor D2; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor; D2R; D2DR; |
Gene ID : | 1813 |
mRNA Refseq : | NM_016574 |
Protein Refseq : | NP_057658 |
MIM : | 126450 |
UniProt ID : | P14416 |
Chromosome Location : | 11q22-q23 |
Pathway : | Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; |
Function : | G-protein coupled receptor activity; dopamine binding; dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity, coupled via Gi/Go; drug binding; drug binding; ionotropic glutamate receptor binding; potassium channel regulator activity; protein binding; receptor activity; receptor binding; signal transducer activity; |
Products Types
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DRD2-16H | Recombinant Human DRD2 Protein, His-tagged | +Inquiry |
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DRD2-17H | Recombinant Human DRD2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DRD2-6817HCL | Recombinant Human DRD2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1215 | cAMP DRD2 (Short Isoform) CHO-K1 GPCR Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTargeting DRD2 could treat disorders like Parkinson's and schizophrenia.
Genetic variations in DRD2 influence behavioral and mental health responses.
It regulates motor control via dopamine pathways.
DRD2 collaborates with other dopamine receptors in brain functions.
DRD2 modulates neurotransmitter signaling in the brain.
DRD2 is key in psychiatric conditions, affecting mood and cognition.
Altered DRD2 activity is linked to addiction, affecting reward mechanisms.
Customer Reviews (3)
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