Recombinant Human DSE Protein, GST-tagged

• Cat.No.: DSE-2888H
• Product Overview: Human DSE full-length ORF ( NP_037484.1, 1 a.a. - 958 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 136.2 kDa
• AA Sequence: MRTHTRGAPSVFFIYLLCFVSAYIT DENPEVMIPFTNANYDSHPMLYFSR AEVAELQLRAASSHEHIAARLTEAV HTMLSSPLEYLPPWDPKDYSARWNE IFGNNLGALAMFCVLYPENIEARDM AKDYMERMAAQPSWLVKDAPWDEVP LAHSLVGFATAYDFLYNYLSKTQQE KFLEVIANASGYMYETSYRRGWGFQ YLHNHQPTNCMALLTGSLVLMNQGY LQEAYLWTKQVLTIMEKSLVLLREV TDGSLYEGVAYGSYTTRSLFQYMFL VQRHFNINHFGHPWLKQHFAFMYRT ILPGFQRTVAIADSNYNWFYGPESQ LVFLDKFVMRNGSGNWLADQIRRNR VVEGPGTPSKGQRWCTLHTEFLWYD GSLKSVPPPDFGTPTLHYFEDWGVV TYGSALPAEINRSFLSFKSGKLGGR AIYDIVHRNKYKDWIKGWRNFNAGH EHPDQNSFTFAPNGVPFITEALYGP KYTFFNNVLMFSPAVSKSCFSPWVG QVTEDCSSKWSKYKHDLAASCQGRV VAAEEKNGVVFIRGEGVGAYNPQLN LKNVQRNLILLHPQLLLLVDQIHLG EESPLETAASFFHNVDVPFEETVVD GVHGAFIRQRDGLYKMYWMDDTGYS EKATFASVTYPRGYPYNGTNYVNVT MHLRSPITRAAYLFIGPSIDVQSFT VHGDSQQLDVFIATSKHAYATYLWT GEATGQSAFAQVIADRHKILFDRNS AIKSSIVPEVKDYAAIVEQNLQHFK PVFQLLEKQILSRVRNTASFRKTAE RLLRFSDKRQTEEAIDRIFAISQQQ QQQSKSKKNRRAGKRYKFVDAVPDI FAQIEVNEKKIRQKAQILAQKELPI DEDEEMKDLLDFADVTYEKHKNGGL IKGRFGQARMVTTTHSRAPSLSASY TRLFLILNIAIFFVMLAMQLTYFQR AQSLHGQRCLYAVLLIDSCILLWLY SSCSQSQC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DSE dermatan sulfate epimerase [ Homo sapiens ]
• Official Symbol: DSE
• Synonyms: DSE; dermatan sulfate epimerase; SART2, squamous cell carcinoma antigen recognized by T cells 2; dermatan-sulfate epimerase; DSEPI; DS epimerase; chondroitin-glucuronate 5-epimerase; squamous cell carcinoma antigen recognized by T cells 2; squamous cell carcinoma antigen recognized by T-cells 2; DSEP; SART2; SART-2
• Gene ID: 29940
• mRNA Refseq: NM_001080976
• Protein Refseq: NP_001074445
• MIM: 605942
• UniProt ID: Q9UL01