Recombinant Human DUOXA1 Protein, GST-tagged DUOXA1-2916H

Recombinant Human DUOXA1 Protein, GST-tagged

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Recombinant Human DUOXA1 Protein, GST-tagged

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Cat.No. : DUOXA1-2916H
Product Overview : Human DUOXA1 full-length ORF ( NP_653166.2, 1 a.a. - 483 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 79.9 kDa
AA Sequence : MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS LFIGAAILAV NFSSEWSVGQ VSTNTSYKAF SSEWISADIG LQVGLGGVNI TLTGTPVQQL NETINYNEEF TWRLGENYAE EYAKALEKGL PDPVLYLAEK FTPRSPCGLY RQYRLAGHYT SAMLWVAFLC WLLANVMLSM PVLVYGGYML LATGIFQLLA LLFFSMATSL TSPCPLHLGA SVLHTHHGPA FWITLTTGLL CVLLGLAMAV AHRMQPHRLK AFFNQSVDED PMLEWSPEEG GLLSPRYRSM ADSPKSQDIP LSEASSTKAY YRPRRLSLVP ADVRGLAPAA LSALPGALLA QAWRALLPGL RCPKAGKESR LGPPHSPWRF GPEGCEERWA EHTGDSPRPL RGRGTGRLWR WGSKERRACG VRAMLPRLVS NSGLKRPSCL DLPKCWDYRR DARAFFHLLE PTPCVTSRHT PLI
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : DUOXA1 dual oxidase maturation factor 1 [ Homo sapiens ]
Official Symbol : DUOXA1
Synonyms : DUOXA1; dual oxidase maturation factor 1; FLJ32334; mol; NIP; NUMBIP; dual oxidase activator 1; numb-interacting protein; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; homolog of Drosophila Numb-interacting protein;
Gene ID : 90527
mRNA Refseq : NM_144565
Protein Refseq : NP_653166
MIM : 612771
UniProt ID : Q1HG43
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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