Recombinant Human DUT Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human DUT Protein, Myc/DDK-tagged, C13 and N15-labeled

DUT Related Products

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Cat.No. : DUT-3772H
Product Overview : DUT MS Standard C13 and N15-labeled recombinant protein (NP_001939) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 17.6 kDa
AA Sequence : MPCSEETPAI SPSKRARPAE VGGMQLRFAR LSEHATAPTR GSARAAGYDL YSAYDYTIPP MEKAVVKTDI QIALPSGCYG RVAPRSGLAA KHFIDVGAGV IDEDYRGNVG VVLFNFGKEK FEVKKGDRIA QLICERIFYP EIEEVQALDD TERGSGGFGS TGKNTRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : DUT deoxyuridine triphosphatase [ Homo sapiens (human) ]
Official Symbol : DUT
Synonyms : DUT; deoxyuridine triphosphatase; dUTP pyrophosphatase; deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial; dUTPase; dUTP nucleotidohydrolase; FLJ20622;
Gene ID : 1854
mRNA Refseq : NM_001948
Protein Refseq : NP_001939
MIM : 601266
UniProt ID : P33316

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