| Description : |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
| Conjugation : |
Fc |
| Tissue specificity : |
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. |
| Biological activity : |
The ED50 of EGFR-28395TH is typically 60-100 ng/ml as measured by its ability to neutralize EGF mediated proliferation of murine NIH3T3 fibroblasts. |
| Form : |
Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not rec |
| Purity : |
>95% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
| Storage : |
Store at +4°C. |
| Sequences of amino acids : |
Theoretical sequence:LEEKKVCQGTSNKLTQLGTFEDHFL SLQR MFNNCEVVLGNLEITYVQRNYDLSF LKTIQEVAGYVLI ALNTVERIPLENLQIIRGNMYYENS YALAVLSNYDANK TGLKELPMRNLQEILHGAVRFSNNP ALCNVESIQWRDIVSSDFLSNMSMD FQNHLGSCQKCDPSCPNGSCWGAGE ENC QKLTKIICAQQCSGRCRGKSPSDCC HNQCAAGCTGPRE SDCLVCRKFRDEATCKDTCPPLMLY NPTTYQMDVNPEG KYSFGATCVKKCPRNYVVTDHGSCV RACGADSYEMEED GVRKCKKCEGPCRKVCNGIGIGEFK DSLSINATNIKHFKNCTSISGDLHI LPVAFRGDSFTHTPPLDPQELDILK TVK EITGFLLIQAWPENRTDLHAFENLE IIRGRTKQHGQFS LAVVSLNITSLGLRSLKEISDGDVI ISGNKNLCYANTI NWKKLFGTSGQKTKIISNRGENSCK ATGQVCHALCSPE GCWGPEPRDCVSRSSNTKVDKKVEP KSCDKTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISRTPEVTCVVVDVS HED PEVKFNWYVDGVEVHNAKTKPREEQ YNSTYRVVSVLTV LHQDWLNGKEYKCKVSNKALPAPIE KTISKAKGQPREP QVYTLPPSRDELTKNQVSLTCLVKG FYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK |
| Sequence Similarities : |
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.Contains 1 protein kinase domain. |
