Recombinant Human erbB-2, Fc-his-tag
Cat.No. : | ERBB2-81H |
Product Overview : | Recombinant Human Her-2/neu(erbB-2)-Fc, was expressed in NSO cells, amino acids 630((23-652aa), IgG-Fc (100-330aa) his-tag fusion protein |
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Species : | Human |
Source : | Mammalian Cells |
Tag : | Fc&His |
Protein Length : | 23-652 a.a. |
Description : | HER2/neu (also known as ErbB-2, ERBB2) is a protein highly expressed in breast cancers.The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
Molecular Mass : | ~130 kda under reducing conditions |
Purity : | >95% |
Usage : | This item is for LABORATORY RESEARCH USE ONLY. |
Gene Name | ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ] |
Official Symbol | ERBB2 |
Synonyms | ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu; |
Gene ID | 2064 |
mRNA Refseq | NM_001005862 |
Protein Refseq | NP_001005862 |
MIM | 164870 |
UniProt ID | P04626 |
Chromosome Location | 17q11.2-q12 |
Pathway | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcium signaling pathway, organism-specific biosystem; |
Function | ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; RNA polymerase I core binding; epidermal growth factor-activated receptor activity; glycoprotein binding; contributes_to growth factor binding; identical protein binding; nucleotide binding; protein C-terminus binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; |
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Not For Human Consumption!
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