"ERBB2" Related Products

Recombinant Human ERBB2 protein, DDK-tagged

Cat.No.: ERBB2-204H
Product Overview: Recombinant Human ERBB2(Lys676-Val1255) fused with DDK tag at C-terminal was expressed in Insect cells.
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Source: Insect cells
Species: Human
Tag : DDK
Form: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol.
Molecular Mass: 64 kDa
Protein length: Lys676-Val1255
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: ERBB2 erb-b2 receptor tyrosine kinase 2 [ Homo sapiens ]
Official Symbol: ERBB2
Synonyms: ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu;
Gene ID: 2064
mRNA Refseq: NM_004448
Protein Refseq: NP_004439
MIM: 164870
UniProt ID: P04626

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