Recombinant Human ERBB4 Protein, GST-tagged
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| Cat.No. : | ERBB4-3450H |
| Product Overview : | Human ERBB4 (NP_005226.1, 676 a.a. - 562 a.a.) full-length recombinant protein with GST tag expressed in Baculovirus infected Sf21 cells. |
| Description : | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| Source : | Insect cells |
| Species : | Human |
| Tag : | GST |
| Form : | Liquid |
| Bio-activity : | The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg (or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000. Substrate: Srctide. ATP: 100 µM. |
| Molecular Mass : | 99 kDa |
| Purity : | 73 % by SDS-PAGE/CBB staining. |
| Applications : | Functional Study SDS-PAGE |
| Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol) |
| Quality Control Testing : |
Loading 1 μg protein in SDS-PAGE |
| Result of activity analysis : |
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| Gene Name : | ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [ Homo sapiens ] |
| Official Symbol : | ERBB4 |
| Synonyms : | ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404; |
| Gene ID : | 2066 |
| mRNA Refseq : | NM_001042599 |
| Protein Refseq : | NP_001036064 |
| MIM : | 600543 |
| UniProt ID : | Q15303 |
◆ Recombinant Protein
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| ERBB4-3451H | Recombinant Human ERBB4 Protein, GST-tagged | +Inquiry |
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| Erbb4-7416M | Recombinant Mouse Erbb4 Protein, His tagged | +Inquiry |
| ERBB4-2116H | Recombinant Human ERBB4 Protein, MYC/DDK-tagged | +Inquiry |
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◆ Lysates
| ERBB4-1543HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
| ERBB4-1417MCL | Recombinant Mouse ERBB4 cell lysate | +Inquiry |
| ERBB4-001HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
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