Recombinant Human ERBB4 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | ERBB4-4240H |
| Product Overview : | ERBB4 MS Standard C13 and N15-labeled recombinant protein (NP_001036064) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 145.2 kDa |
| AA Sequence : | MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE EYLVPQAFNI PPPIYTSRAR IDSNRNQFVY RDGGFAAEQG VSVPYRAPTS TIPEAPVAQG ATAEIFDDSC CNGTLRKPVA PHVQEDSSTQ RYSADPTVFA PERSPRGELD EEGYMTPMRD KPKQEYLNPV EENPFVSRRK NGDLQALDNP EYHNASNGPP KAEDEYVNEP LYLNTFANTL GKAEYLKNNI LSMPEKAKKA FDNPDYWNHS LPPRSTLQHP DYLQEYSTKY FYKQNGRIRP IVAENPEYLS EFSLKPGTVL PPPPYRHRNT VVTRTRPLEQ KLISEEDLAA NDILDYKDDD DKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | ERBB4 erb-b2 receptor tyrosine kinase 4 [ Homo sapiens (human) ] |
| Official Symbol : | ERBB4 |
| Synonyms : | ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404; |
| Gene ID : | 2066 |
| mRNA Refseq : | NM_001042599 |
| Protein Refseq : | NP_001036064 |
| MIM : | 600543 |
| UniProt ID : | Q15303 |
◆ Recombinant Protein
| ERBB4-2052H | Recombinant Human ERBB4 Protein, Fc/His-tagged | +Inquiry |
| ERBB4-3451H | Recombinant Human ERBB4 Protein, GST-tagged | +Inquiry |
| Erbb4-7416M | Recombinant Mouse Erbb4 Protein, His tagged | +Inquiry |
| Erbb4-971M | Recombinant Mouse Erbb4 Protein, MYC/DDK-tagged | +Inquiry |
| ERBB4-3450H | Recombinant Human ERBB4 Protein, GST-tagged | +Inquiry |
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◆ Lysates
| ERBB4-1543HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
| ERBB4-1417MCL | Recombinant Mouse ERBB4 cell lysate | +Inquiry |
| ERBB4-895RCL | Recombinant Rat ERBB4 cell lysate | +Inquiry |
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