| Description : |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
145.2 kDa |
| AA Sequence : |
MKPATGLWVWVSLLVAAGTVQPSDS QSVCAGTENKLSSLSDLEQQYRALR KYYENCEVVMGNLEITSIEHNRDLS FLRSVREVTGYVLVALNQFRYLPLE NLRIIRGTKLYEDRYALAIFLNYRK DGNFGLQELGLKNLTEILNGGVYVD QNKFLCYADTIHWQDIVRNPWPSNL TLVSTNGSSGCGRCHKSCTGRCWGP TENHCQTLTRTVCAEQCDGRCYGPY VSDCCHRECAGGCSGPKDTDCFACM NFNDSGACVTQCPQTFVYNPTTFQL EHNFNAKYTYGAFCVKKCPHNFVVD SSSCVRACPSSKMEVEENGIKMCKP CTDICPKACDGIGTGSLMSAQTVDS SNIDKFINCTKINGNLIFLVTGIHG DPYNAIEAIDPEKLNVFRTVREITG FLNIQSWPPNMTDFSVFSNLVTIGG RVLYSGLSLLILKQQGITSLQFQSL KEISAGNIYITDNSNLCYYHTINWT TLFSTINQRIVIRDNRKAENCTAEG MVCNHLCSSDGCWGPGPDQCLSCRR FSRGRICIESCNLYDGEFREFENGS ICVECDPQCEKMEDGLLTCHGPGPD NCTKCSHFKDGPNCVEKCPDGLQGA NSFIFKYADPDRECHPCHPNCTQGC NGPTSHDCIYYPWTGHSTLPQHART PLIAAGVIGGLFILVIVGLTFAVYV RRKSIKKKRALRRFLETELVEPLTP SGTAPNQAQLRILKETELKRVKVLG SGAFGTVYKGIWVPEGETVKIPVAI KILNETTGPKANVEFMDEALIMASM DHPHLVRLLGVCLSPTIQLVTQLMP HGCLLEYVHEHKDNIGSQLLLNWCV QIAKGMMYLEERRLVHRDLAARNVL VKSPNHVKITDFGLARLLEGDEKEY NADGGKMPIKWMALECIHYRKFTHQ SDVWSYGVTIWELMTFGGKPYDGIP TREIPDLLEKGERLPQPPICTIDVY MVMVKCWMIDADSRPKFKELAAEFS RMARDPQRYLVIQGDDRMKLPSPND SKFFQNLLDEEDLEDMMDAEEYLVP QAFNIPPPIYTSRARIDSNRNQFVY RDGGFAAEQGVSVPYRAPTSTIPEA PVAQGATAEIFDDSCCNGTLRKPVA PHVQEDSSTQRYSADPTVFAPERSP RGELDEEGYMTPMRDKPKQEYLNPV EENPFVSRRKNGDLQALDNPEYHNA SNGPPKAEDEYVNEPLYLNTFANTL GKAEYLKNNILSMPEKAKKAFDNPD YWNHSLPPRSTLQHPDYLQEYSTKY FYKQNGRIRPIVAENPEYLSEFSLK PGTVLPPPPYRHRNTVVTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
