Recombinant Human ESRRG Protein, GST-tagged

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Recombinant Human ESRRG Protein, GST-tagged

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Cat.No. : ESRRG-3511H
Product Overview : Human ESRRG full-length ORF ( AAH64700, 1 a.a. - 442 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 74.36 kDa
AA Sequence : MSNKDRHIDS SCSSFIKTEP SSPASLTDSV NHHSPGGSSD ASGSYSSTMN GHQNGLDSPP LYPSAPILGG SGPVRKLYDD CSSTIVEDPQ TKCEYMLNSM PKRLCLVCGD IASGYHYGVA SCEACKAFFK RTIQGNIEYS CPATNECEIT KRRRKSCQAC RFMKCLKVGM LKEGVRLDRV RGGRQKYKRR IDAENSPYLN PQLVQPAKKP LLWSDPADNK IVSHLLVAEP EKIYAMPDPT APDSDIKALT TLCDLADREL VVIIGWAKHI PGFSTLSLAD QMSLLQSAWM EILILGVVYR SLSFEDELVY ADDYIMDEDQ SKLAGLLDLN NAILQLVKKY KSMKLEKEEF VTLKAIALAN SDSMHIEDVE AVQKLQDVLH EALQDYEAGQ HMEDPRRAGK MLMTLPLLRQ TSTKAVQHFY NIKLEGKVPM HKLLLEMLEA KV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : ESRRG estrogen-related receptor gamma [ Homo sapiens ]
Official Symbol : ESRRG
Synonyms : ESRRG; estrogen-related receptor gamma; ERR gamma-2; estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3; ERR3; NR3B3; ERRgamma; FLJ16023; KIAA0832; DKFZp781L1617;
Gene ID : 2104
mRNA Refseq : NM_001134285
Protein Refseq : NP_001127757
MIM : 602969
UniProt ID : P62508

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