Recombinant Human EXOSC3, GST-tagged

• Cat.No.: EXOSC3-12596H
• Product Overview: Recombinant Human EXOSC3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-275a.a.
• Description: This gene encodes a non-catalytic component of the human exosome, a complex with 3-5 exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: EXOSC3 exosome component 3 [ Homo sapiens ]
• Official Symbol: EXOSC3
• Synonyms: EXOSC3; exosome component 3; exosome complex component RRP40; CGI 102; CGI 102 protein; exosome component Rrp40; hRrp 40; hRrp40p; p10; RRP40; Rrp40p; exosome complex exonuclease RRP40; ribosomal RNA-processing protein 40; CGI-102; hRrp-40; bA3J10.7; MGC723; RP11-3J10.8; MGC15120
• Gene ID: 51010
• mRNA Refseq: NM_001002269
• Protein Refseq: NP_001002269
• MIM: 606489
• UniProt ID: Q9NQT5
• Chromosome Location: 9p11
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem
• Function: 3-5-exoribonuclease activity; RNA binding; NOT exoribonuclease activity; protein binding