| Description : |
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
87.7 kDa |
| AA Sequence : |
MKTWVKIVFGVATSAVLALLVMCIV LRPSRVHNSEENTMRALTLKDILNG TFSYKTFFPNWISGQEYLHQSADNN IVLYNIETGQSYTILSNRTMKSVNA SNYGLSPDRQFVYLESDYSKLWRYS YTATYYIYDLSNGEFVRGNELPRPI QYLCWSPVGSKLAYVYQNNIYLKQR PGDPPFQITFNGRENKIFNGIPDWV YEEEMLATKYALWWSPNGKFLAYAE FNDTDIPVIAYSYYGDEQYPRTINI PYPKAGAKNPVVRIFIIDTTYPAYV GPQEVPVPAMIASSDYYFSWLTWVT DERVCLQWLKRVQNVSVLSICDFRE DWQTWDCPKTQEHIEESRTGWAGGF FVSTPVFSYDAISYYKIFSDKDGYK HIHYIKDTVENAIQITSGKWEAINI FRVTQDSLFYSSNEFEEYPGRRNIY RISIGSYPPSKKCVTCHLRKERCQY YTASFSDYAKYYALVCYGPGIPIST LHDGRTDQEIKILEENKELENALKN IQLPKEEIKKLEVDEITLWYKMILP PQFDRSKKYPLLIQVYGGPCSQSVR SVFAVNWISYLASKEGMVIALVDGR GTAFQGDKLLYAVYRKLGVYEVEDQ ITAVRKFIEMGFIDEKRIAIWGWSY GGYVSSLALASGTGLFKCGIAVAPV SSWEYYASVYTERFMGLPTKDDNLE HYKNSTVMARAEYFRNVDYLLIHGT ADDNVHFQNSAQIAKALVNAQVDFQ AMWYSDQNHGLSGLSTNHLYTHMTH FLKQCFSLSDSGPTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
