Recombinant Human FBN1 Protein, Fc-tagged
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|Product Overview :||Recombinant Human Fibrillin-1 (Ala25-Thr660) protein with Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Chinese Hamster Ovary cell line.|
|Description :||This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome.|
|Form :||Disulfide-linked homodimer|
|Bio-activity :||Measured by its binding ability in a functional ELISA. When Recombinant Human MFAP4 is immobilized at 0.5 μg/mL (100 μL/well), the concentration of Recombinant Human Fibrillin-1/FBN1 Fc Chimera that produces 50% of the optimal binding response is 0.1-0.6 μg/mL.|
|Molecular Mass :||95 kDa|
|N-terminal Sequence Analysis :||Ala25|
|Endotoxin :||< 0.1 EU/μg of the protein by the LAL method.|
|Purity :||> 95%, by SDS-PAGE under reducing conditions and visualized by silver stain.|
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Storage Buffer :||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Reconstitution :||Reconstitute at 500 μg/mL in PBS.|
|Shipping :||The product is shipped at ambient temperature.|
|Binding Activity :||
When Recombinant Human MFAP4 is coated at 0.5 μg/mL, 100 μL/well, Recombinant Human Fibrillin-1/FBN1 Fc Chimera binds with an ED50 of 0.1-0.6 μg/mL.
1 μg/lane of Recombinant Human Fibrillin-1/FBN1 Fc Chimera was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 97-108 kDa and 190-220 kDa, respectively.
|Gene Name :||FBN1 fibrillin 1 [ Homo sapiens (human) ]|
|Official Symbol :||FBN1|
|Synonyms :||FBN1; fibrillin 1; FBN; SGS; WMS; MASS; MFLS; MFS1; OCTD; SSKS; WMS2; ACMICD; ECTOL1; GPHYSD2; fibrillin-1; asprosin; epididymis secretory sperm binding protein; fibrillin 15; fibrillin-1 preproprotein|
|Gene ID :||2200|
|mRNA Refseq :||NM_000138|
|Protein Refseq :||NP_000129|
|UniProt ID :||P35555|
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