Description : |
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
78.7 kDa |
AA Sequence : |
MASSGEDISNDDDDMHPAAAGMADG VHLLGFSDEILLHILSHVPSTDLIL NVRRTCRKLAALCLDKSLIHTVLLQ KDYQASEDKVRQLVKEIGREIQQLS MAGCYWLPGSTVEHVARCRSLVKVN LSGCHLTSLRLSKMLSALQHLRSLA IDVSPGFDASQLSSECKATLSRVRE LKQTLFTPSYGVVPCCTSLEKLLLY FEILDRTREGAILSGQLMVGQSNVP HYQNLRVFYARLAPGYINQEVVRLY LAVLSDRTPQNLHAFLISVPGSFAE SGATKNLLDSMARNVVLDALQLPKS WLNGSSLLQHMKFNNPFYFSFSRCT LSGGHLIQQVINGGKDLRSLASLNL SGCVHCLSPDSLLRKAEDDIDSSIL ETLVASCCNLRHLNLSAAHHHSSEG LGRHLCQLLARLRHLRSLSLPVCSV ADSAPRADRAPAQPAMHAVPRGFGK KVRVGVQSCPSPFSGQACPQPSSVF WSLLKNLPFLEHLELIGSNFSSAMP RNEPAIRNSLPPCSRAQSVGDSEVA AIGQLAFLRHLTLAQLPSVLTGSGL VNIGLQCQQLRSLSLANLGMMGKVV YMPALSDMLKHCKRLRDLRLEQPYF SANAQFFQALSQCPSLQRLCLVSRS GTLQPDAVLAFMARCLQVVMCHLFT GESLATCKSLQQSLLRSFQAERPAL NVVIFPLLHEGLTDVIRDVPLVHLD EITLFKSRVAEEPPNLWWTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |