Recombinant Human FBXW5 Protein, GST-tagged

• Cat.No.: FBXW5-3973H
• Product Overview: Human FBXW5 full-length ORF ( AAH00850.1, 1 a.a. - 159 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
• Molecular Mass: 44.9 kDa
• AA Sequence: MGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FBXW5 F-box and WD repeat domain containing 5 [ Homo sapiens ]
• Official Symbol: FBXW5
• Synonyms: FBXW5; F-box and WD repeat domain containing 5; F box and WD 40 domain protein 5; F-box/WD repeat-containing protein 5; DKFZP434B205; Fbw5; MGC20962; WD repeat-containing F-box protein FBW5; F-box and WD-40 domain-containing protein 5; DKFZp434B205
• Gene ID: 54461
• mRNA Refseq: NM_018998
• Protein Refseq: NP_061871
• MIM: 609072
• UniProt ID: Q969U6