Recombinant Human FBXW7 Protein, GST-tagged

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human FBXW7 Protein, GST-tagged

Recombinant Human FBXW7 Protein, GST-tagged

FBXW7 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : FBXW7-3975H
Product Overview : Human FBXW7 full-length ORF (BAA91986.1, 1 a.a. - 553 a.a.) recombinant protein with GST tag at N-terminal.
Description : This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 88.7 kDa
AA Sequence : MGFYGTLKMI FYKMKRKLDH GSEVRSFSLG KKPCKVSEYT STTGLVPCSA TPTTFGDLRA ANGQGQQRRR ITSVQPPTGL QEWLKMFQSW SGPEKLLALD ELIDSCEPTQ VKHMMQVIEP QFQRDFISLL PKELALYVLS FLEPKDLLQA AQTCRYWRIL AEDNLLWREK CKEEGIDEPL HIKRRKVIKP GFIHSPWKSA YIRQHRIDTN WRRGELKSPK VLKGHDDHVI TCLQFCGNRI VSGSDDNTLK VWSAVTGKCL RTLVGHTGGV WSSQMRDNII ISGSTDRTLK VWNAETGECI HTLYGHTSTV RCMHLHEKRV VSGSRDATLR VWDIETGQCL HVLMGHVAAV RCVQYDGRRV VSGAYDFMVK VWDPETETCL HTLQGHTNRV YSLQFDGIHV VSGSLDTSIR VWDVETGNCI HTLTGHQSLT SGMELKDNIL VSGNADSTVK IWDIKTGQCL QTLQGPNKHQ SAVTCLQFNK NFVITSSDDG TVKLWDLKTG EFIRNLVTLE SGGSGGVVWR IRASNTKLVC AVGSRNGTEE TKLLVLDFDV DMK
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue

Gene Name : FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : FBXW7
Synonyms : FBXW7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F box and WD repeat domain containing 7 , F box and WD 40 domain protein 7 (archipelago homolog, Drosophila); F-box/WD repeat-containing protein 7; AGO; archipelago homolog (Drosophila); CDC4; FBW7; FBX30; FBXW6; FLJ11071; SEL 10; SEL10; archipelago; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; homolog of C elegans sel-10; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); FBW6; hAgo; hCdc4; FBXO30; SEL-10; FLJ16457; DKFZp686F23254;
Gene ID : 55294
mRNA Refseq : NM_001013415
Protein Refseq : NP_001013433
MIM : 606278
UniProt ID : Q969H0

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy