Recombinant Human FGFR1 Protein, GST-tagged
Cat.No. : | FGFR1-4123H |
Product Overview : | Human FGFR1 full-length ORF ( NP_075594.1, 1 a.a. - 731 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 108.3 kDa |
AA Sequence : | MWSWKCLLFWAVLVTATLCTARPSP TLPEQDALPSSEDDDDDDDSSSEEK ETDNTKPNPVAPYWTSPEKMEKKLH AVPAAKTVKFKCPSSGTPNPTLRWL KNGKEFKPDHRIGGYKVRYATWSII MDSVVPSDKGNYTCIVENEYGSINH TYQLDVVERSPHRPILQAGLPANKT VALGSNVEFMCKVYSDPQPHIQWLK HIEVNGSKIGPDNLPYVQILKTAGV NTTDKEMEVLHLRNVSFEDAGEYTC LAGNSIGLSHHSAWLTVLEALEERP AVMTSPLYLEIIIYCTGAFLISCMV GSVIVYKMKSGTKKSDFHSQMAVHK LAKSIPLRRQVTVSADSSASMNSGV LLVRPSRLSSSGTPMLAGVSEYELP EDPRWELPRDRLVLGKPLGEGCFGQ VVLAEAIGLDKDKPNRVTKVAVKML KSDATEKDLSDLISEMEMMKMIGKH KNIINLLGACTQDGPLYVIVEYASK GNLREYLQARRPPGLEYCYNPSHNP EEQLSSKDLVSCAYQVARGMEYLAS KKCIHRDLAARNVLVTEDNVMKIAD FGLARDIHHIDYYKKTTNGRLPVKW MAPEALFDRIYTHQSDVWSFGVLLW EIFTLGGSPYPGVPVEELFKLLKEG HRMDKPSNCTNELYMMMRDCWHAVP SQRPTFKQLVEDLDRIVALTSNQEY LDLSMPLDQYSPSFPDTRSSTCSSG EDSVFSHEPLPEEPCLPRHPAQLAN GGLKRR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ] |
Official Symbol : | FGFR1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2, KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988; |
Gene ID : | 2260 |
mRNA Refseq : | NM_001174063 |
Protein Refseq : | NP_001167534 |
MIM : | 136350 |
UniProt ID : | P11362 |
Products Types
◆ Recombinant Protein | ||
FGFR1-91H | Recombinant Active Human FGFR1 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
FGFR1-4122H | Recombinant Human FGFR1 Protein | +Inquiry |
FGFR1-1526R | Recombinant Rhesus Macaque FGFR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FGFR1-2056H | Recombinant Human FGFR1 Protein, His-tagged | +Inquiry |
FGFR1-5417H | Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged | +Inquiry |
◆ Lysates | ||
FGFR1-476HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
FGFR1-2765HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
FGFR1-2133MCL | Recombinant Mouse FGFR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1557 | U2OS FGFR1 Bioassay Kit | +Inquiry |
Kit-1590 | FGFR1 Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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