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Recombinant Human Fibroblast Growth Factor-basic

Cat.No. : FGF2-11H
Product Overview : Recombinant Human Fibroblast Growth Factor-basic produced inE.coliis a single non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of approximately 17.3KDa
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Cat. No. : FGF2-11H
Description : bFGF is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5 , FGF-6 , K-FGF and KGF (keratinocyte growth factor =FGF-7). All factors are products of different genes, some of which are Oncogene products ( FGF-3, FGF-4, FGF-5).
Purity : >98% by SDS-PAGE and HPLC analyses.
Formulation : Lyophilized from a 0.2mm filtered solution in PBS, pH 7.4.
Biological Activity : Fully biologically active when compared to standard. The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5 ng/ml, corresponding to a specific activity of (2.0 x 106) Units/mg.
Endotoxin : Less than 1EU/mg of rHubFGF as determined by LAL method.
Reconstitutionon : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storagee : This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Publication :
Dual pH-and temperature-responsive microparticles for protein delivery to ischemic tissues. (2013)
Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele (2019)
Gene Name : FGF2
Synonyms : DN-452A22.6; Fgf-2; Fgfb; bFGF; Prostatropin; fibroblast growth factor 2 (basic); Basic fibroblast growth factor; Heparin-binding growth factor 2 precursor; heparin-binding growth factor 2; Heparin-binding growth factor 2 precursor; basic fibroblast growth factor bFGF; fibroblast growth factor 2; FGF2
Gene ID : 2247
mRNA Refseq : NM_002006.4
Protein Refseq : NP_001997.5
MIM : 134920
UniProt ID : P09038
Chromosome Location : 4q26-q27
Pathway : MAPK signaling pathway; Prostate cancer; Regulation of actin cytoskeleton
Function : growth factor activity; hepatin binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.


      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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