Recombinant Human FLT3 Protein, MYC/DDK-tagged FLT3-2340H

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Recombinant Human FLT3 Protein, MYC/DDK-tagged

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Cat.No. :	FLT3-2340H
Product Overview :	Recombinant human FLT3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description :	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Source :	HEK293
Species :	Human
Tag :	MYC/DDK
Form :	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass :	112.7 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration :	>50 ug/mL as determined by microplate BCA method

Gene Name :	FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Official Symbol :	FLT3
Synonyms :	CD135; FLK-2; FLK2; STK1
Gene ID :	2322
mRNA Refseq :	NM_004119
Protein Refseq :	NP_004110
MIM :	136351
UniProt ID :	P36888