Recombinant Human FMO1, GST-tagged
Cat.No. : | FMO1-119H |
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ProductOverview : | Recombinant Human FMO1(1 aa. - 532 aa), fused with aN-terminal GST tag, was expressed in Wheat germ. |
Description : | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. |
Species : | Human |
Source : | Wheat germ |
MolecularMass : | 84.26kDa |
AA Sequence : | MAKRVAIVGAGVSGLASIKCCLEEG LEPTCFERSDDLGGLWRFTEHVEEG RASLYKSVVSNSCKEMSCYSDFPFP EDYPNYVPNSQFLEYLKMYANHFDL LKHIQFKTKVCSVTKCSDSAVSGQW EVVTMHEEKQESAIFDAVMVCTGFL TNPYLPLDSFPGINAFKGQYFHSRQ YKHPDIFKDKRVLVIGMGNSGTDIA VEASHLAEKVFLSTTGGGWVISRIF DSGYPWDMVFMTRFQNMLRNSLPTP IVTWLMERKINNWLNHANYGLIPED RTQLKEFVLNDELPGRIITGKVFIR PSIKEVKENSVIFNNTSKEEPIDII VFATGYTFAFPFLDESVVKVEDGQA SLYKYIFPAHLQKPTLAIIGLIKPL GSMIPTGETQARWAVRVLKGVNKLP PPSVMIEEINARKENKPSWFGLCYC KALQSDYITYIDELLTYINAKPNLF SMLLTDPHLALTVFFGPCSPYQFRL TGPGKWEGARNAIMTQWDRTFKVIK ARVVQESPSPFESFLKVFSFLALLV AIFLIFL |
StorageBuffer : | 50 mMTris-HCI, 10 mM reduced Glutathione, pH8.0 in the elution buffer. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Protein length : | 1-532 |
Gene Name : | FMO1 flavin containing monooxygenase 1 [ Homo sapiens ] |
Official Symbol : | FMO1 |
Synonyms : | flavin containing monooxygenase 1; FMO1; dimethylanilinemonooxygenase [N-oxide-forming] 1; FMO 1; OTTHUMP00000033537; dimethylaniline oxidase 1; Flavin-containing monooxygenase 1 (fetal liver); fetal hepatic flavin-containing monooxygenase 1; Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; EC 1.14.13.8 |
Gene ID : | 2326 |
mRNA Refseq : | NM_002021 |
Protein Refseq : | NP_002012 |
MIM : | 136130 |
UniProt ID : | Q01740 |
Chromosome Location : | 1q23-q25 |
Pathway : | Drug metabolism - cytochrome P450; Biological oxidations |
Function : | FAD binding; NADP or NADPH binding; binding; flavin-containing monooxygenase activity; monooxygenase activity |
Products Types
◆ Recombinant Protein | ||
FMO1-240H | Recombinant Human FMO1 Protein, His-tagged | +Inquiry |
FMO1-3289M | Recombinant Mouse FMO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FMO1-2023R | Recombinant Rat FMO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FMO1-5937M | Recombinant Mouse FMO1 Protein | +Inquiry |
FMO1-2367R | Recombinant Rat FMO1 Protein | +Inquiry |
◆ Lysates | ||
FMO1-282HCL | Recombinant Human FMO1 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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