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Recombinant Human FRS2 protein, MYC/DDK-tagged

Cat.No. : FRS2-23H
Product Overview : Recombinant Human FRS2, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : FRS2 played an important role in many functions.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 56.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : FRS2 fibroblast growth factor receptor substrate 2 [ Homo sapiens ]
Official Symbol : FRS2
Synonyms : FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1; SNT; SNT-1;
Gene ID : 10818
mRNA Refseq : NM_006654
Protein Refseq : NP_006645
MIM : 607743
UniProt ID : Q8WU20
Chromosome Location : 12q15
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; Frs2-mediated activation, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Function : fibroblast growth factor receptor binding; insulin receptor binding; neurotrophin TRKA receptor binding; phosphatase activator activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of FRS2 protein in the pathogenesis of insulin resistance? 10/27/2022

FRS2 protein regulates signal transduction of insulin receptors, so its abnormal expression or function can lead to the pathogenesis of insulin resistance.

How is FRS2 involved in hepatocyte differentiation and carcinogenesis? 12/05/2021

FRS2 plays an important role in the proliferation and differentiation of hepatocytes, and no good regulation will lead to hepatocyte transformation and carcinogenesis.

What is the potential role of FRS2 protein in cancer treatment? 12/26/2020

FRS2 protein can be considered a potential target for the treatment of certain types of cancer, so drug research is expected to further explore this effect.

How does FRS2 protein regulate bone metabolism? 07/07/2020

The bone metabolism regulated by FRS2 protein is related to bone formation and bone resorption, and plays a role by affecting the signaling and function of bone cells.

How does FRS2 protein regulate signal transduction of insulin receptors? 01/03/2020

The protein can affect insulin metabolism by binding to insulin receptors and other proteins to regulate downstream signaling of insulin receptors.

What are the conditions caused by defects in FRS2 protein? 02/09/2019

Defects in the FRS2 protein can lead to the development of pathopathologies such as insulin resistance, obesity, bone metabolism disorders, and neurodegenerative diseases.

Customer Reviews (3)

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Reviews
12/28/2021

    The catalytic activity of FRS2 is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.

    08/31/2021

      Stability of FRS2 is very high, and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.

      02/03/2019

        The production process of FRS2 uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, bringing a positive impact on the environment.

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