Recombinant Human FTCD, His-tagged

• Cat.No.: FTCD-13023H
• Product Overview: Recombinant Human FTCD protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-350a.a.
• Description: The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FTCD formiminotransferase cyclodeaminase [ Homo sapiens ]
• Official Symbol: FTCD
• Synonyms: FTCD; formiminotransferase cyclodeaminase; formimidoyltransferase-cyclodeaminase; formiminotransferase-cyclodeaminase; formimidoyltransferase cyclodeaminase; LCHC1
• Gene ID: 10841
• mRNA Refseq: NM_006657
• Protein Refseq: NP_006648
• MIM: 606806
• UniProt ID: O95954
• Chromosome Location: 21q22.3
• Pathway: Histidine catabolism, organism-specific biosystem; Histidine metabolism, organism-specific biosystem; Histidine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; One Carbon Metabolism, organism-specific biosystem
• Function: folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; lyase activity; transferase activity