Recombinant Human GATM Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: GATM-5393H
• Product Overview: GATM MS Standard C13 and N15-labeled recombinant protein (NP_001473) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.5 kDa
• AA Sequence: MLRVRCLRGGSRGAEAVHYIGSRLG RTLTGWVQRTFQSTQAATASSRNSC AADDKATEPLPKDCPVSSYNEWDPL EEVIVGRAENACVPPFTIEVKANTY EKYWPFYQKQGGHYFPKDHLKKAVA EIEEMCNILKTEGVTVRRPDPIDWS LKYKTPDFESTGLYSAMPRDILIVV GNEIIEAPMAWRSRFFEYRAYRSII KDYFHRGAKWTTAPKPTMADELYNQ DYPIHSVEDRHKLAAQGKFVTTEFE PCFDAADFIRAGRDIFAQRSQVTNY LGIEWMRRHLAPDYRVHIISFKDPN PMHIDATFNIIGPGIVLSNPDRPCH QIDLFKKAGWTIITPPTPIIPDDHP LWMSSKWLSMNVLMLDEKRVMVDAN EVPIQKMFEKLGITTIKVNIRNANS LGGGFHCWTCDVRRRGTLQSYLDTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GATM glycine amidinotransferase [ Homo sapiens (human) ]
• Official Symbol: GATM
• Synonyms: GATM; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; AGAT; transamidinase; L-arginine:glycine amidinotransferase; AT
• Gene ID: 2628
• mRNA Refseq: NM_001482
• Protein Refseq: NP_001473
• MIM: 602360
• UniProt ID: P50440