| Description : |
This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
168.4 kDa |
| AA Sequence : |
MGQEPRTLPPSPNWYCARCSDAVPG GLFGFAARTSVFLVRVGPGAGESPG TPPFRVIGELVGHTERVSGFTFSHH PGQYNLCATSSDDGTVKIWDVETKT VVTEHALHQHTISTLHWSPRVKDLI VSGDEKGVVFCYWFNRNDSQHLFIE PRTIFCLTCSPHHEDLVAIGYKDGI VVIIDISKKGEVIHRLRGHDDEIHS IAWCPLPGEDCLSINQEETSEEAEI TNGNAVAQAPVTKGCYLATGSKDQT IRIWSCSRGRGVMILKLPFLKRRGG GIDPTVKERLWLTLHWPSNQPTQLV SSCFGGELLQWDLTQSWRRKYTLFS ASSEGQNHSRIVFNLCPLQTEDDKQ LLLSTSMDRDVKCWDIATLECSWTL PSLGGFAYSLAFSSVDIGSLAIGVG DGMIRVWNTLSIKNNYDVKNFWQGV KSKVTALCWHPTKEGCLAFGTDDGK VGLYDTYSNKPPQISSTYHKKTVYT LAWGPPVPPMSLGGEGDRPSLALYS CGGEGIVLQHNPWKLSGEAFDINKL IRDTNSIKYKLPVHTEISWKADGKI MALGNEDGSIEIFQIPNLKLICTIQ QHHKLVNTISWHHEHGSQPELSYLM ASGSNNAVIYVHNLKTVIESSPESP VTITEPYRTLSGHTAKITSVAWSPH HDGRLVSASYDGTAQVWDALREEPL CNFRGHRGRLLCVAWSPLDPDCIYS GADDFCVHKWLTSMQDHSRPPQGKK SIELEKKRLSQPKAKPKKKKKPTLR TPVKLESIDGNEEESMKENSGPVEN GVSDQEGEEQAREPELPCGLAPAVS REPVICTPVSSGFEKSKVTINNKVI LLKKEPPKEKPETLIKKRKARSLLP LSTSLDHRSKEELHQDCLVLATAKH SRELNEDVSADVEERFHLGLFTDRA TLYRMIDIEGKGHLENGHPELFHQL MLWKGDLKGVLQTAAERGELTDNLV AMAPAAGYHVWLWAVEAFAKQLCFQ DQYVKAASHLLSIHKVYEAVELLKS NHFYREAIAIAKARLRPEDPVLKDL YLSWGTVLERDGHYAVAAKCYLGAT CAYDAAKVLAKKGDAASLRTAAELA AIVGEDELSASLALRCAQELLLANN WVGAQEALQLHESLQGQRLVFCLLE LLSRHLEEKQLSEGKSSSSYHTWNT GTEGPFVERVTAVWKSIFSLDTPEQ YQEAFQKLQNIKYPSATNNTPAKQL LLHICHDLTLAVLSQQMASWDEAVQ ALLRAVVRSYDSGSFTIMQEVYSAF LPDGCDHLRDKLGDHQSPATPAFKS LEAFFLYGRLYEFWWSLSRPCPNSS VWVRAGHRTLSVEPSQQLDTASTEE TDPETSQPEPNRPSELDLRLTEEGE RMLSTFKELFSEKHASLQNSQRTVA EVQETLAEMIRQHQKSQLCKSTANG PDKNEPEVEAEQPLCSSQSQCKEEK NEPLSLPELTKRLTEANQRMAKFPE SIKAWPFPDVLECCLVLLLIRSHFP GCLAQEMQQQAQELLQKYGNTKTYR RHCQTFCMTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
