| Description : |
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
22.26 kDa |
| Protein Length : |
638 |
| AA Sequence : |
MDLWQLLLTLALAGSSDAFSGSEAT AAILSRAPWSLQSVNPGLKTNSSKE PKFTKCRSPERETFSCHWTDEVHHG TKNLGPIQLFYTRRNTQEWTQEWKE CPDYVSAGENSCYFNSSFTSIWIPY CIKLTSNGGTVDEKCFSVDEIVQPD PPIALNWTLLNVSLTGIHADIQVRW EAPRNADIQKGWMVLEYELQYKEVN ETKWKMMDPILTTSVPVYSLKVDKE YEVRVRSKQRNSGNYGEFSEVLYVT LPQMSQFTCEEDFYFPWLLIIIFGI FGLTVMLFVFLFSKQQRIKMLILPP VPVPKIKGIDPDLLKEGKLEEVNTI LAIHDSYKPEFHSDDSWVEFIELDI DEPDEKTEESDTDRLLSSDHEKSHS NLGVKDGDSGRTSCCEPDILETDFN ANDIHEGTSEVAQPQRLKGEADLLC LDQKNQNNSPYHDACPATQQPSVIQ AEKNKPQPLPTEGAESTHQAAHIQL SNPSSLSNIDFYAQVSDITPAGSVV LSPGQKNKAGMSQCDMHPEMVSLCQ ENFLMDNAYFCEADAKKCIPVAPHI KVESHIQPSLNQEDIYITTESLTTA AGRPGTGEHVPGSEMPVPDYTSIHI VQSPQGLILNATALPLPDKEFLSSC GYVSTDQLNKIMP |
| Purity : |
> 98% |
| Applications : |
WB |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
4°C |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
Sodium-phosphate (pH 7.4). Sterile-filtered colorless solution (reconst). |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
