| Description : |
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
| Source : |
CHO |
| Species : |
Human |
| Tag : |
Tag Free |
| Protein length : |
ECD |
| Conjugation/Label : |
Biotin |
| Form : |
Lyophilised |
| Endotoxin : |
Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg). |
| Applications : |
ELISA, WB |
| Notes : |
FOR RESEARCH USE ONLY (RUO). |
| Storage : |
The lyophilized protein is stable for at least 1 year from date of receipt at -20 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 to 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss |
| Storage Buffer : |
Lyophilised from 0.2 μm filtered 20 mM Tris, 50 mM NaCl, pH 7.4. |
| Reconstitution : |
Upon receipt a quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
