Recombinant Human Glycogen Synthase Kinase 3 Alpha

Cat.No. : GSK3A-1133H
Product Overview : The recombinant GSK3A fusion protein serves as a useful substrate for assaying Akt kinase activity.
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Cat. No. : GSK3A-1133H
Description : GSK3A is one of the Akt substrates. It can be phosphorylated by Akt at Ser21 of GSK3A or Ser9 of GSK-3β. The phosphorylation of GSK negatively regulates its kinase activity.
Biological Activity : GSK3A fusion protein at a concentration of 2 µg/20 µl reaction was phosphorylated in an in vitro kinase assay with 200 µM ATP. After 30 minutes incubation at 30°C, phosphorylation was detected by Western blot with phospho-specific GSK3A antibodies.
Molecular Weight : 37.0 kDa
Source : E. coli
Species : Human
Form : Liquid. 2.mg/ml in storage buffer containing 20 mM Tris-HCL (pH 7.5), 50 mM Nacl, 2 mM EDTA, 0.1 Mm DTT, and 50% glycerol.
Appearance : Liquid
Storage : -20°C or -70°C.
Pathways : AKT phosphorylates targets in the cytosol; Activation of Chaperones by IRE1alpha; B Cell Receptor Signaling Pathway; Chemokine signaling pathway; Class I PI3K signaling events mediated by Akt; Diabetes pathways; Dopaminergic synapse; Downstream signaling of activated FGFR; FOXM1 transcription factor network; Glycogen Metabolism; IL-3 Signaling Pathway; IL-5 Signaling Pathway; Insulin Signaling; NGF signalling via TRKA from the plasma membrane; PI-3K cascade
Tag : Non
Gene Name : GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens ]
Official Symbol : GSK3A
Synonyms : GSK3A; glycogen synthase kinase 3 alpha; DKFZp686D0638; Glycogen synthase kinase-3 alpha; GSK-3 alpha; EC 2.7.11.26
Gene ID : 2931
mRNA Refseq : NM_019884
Protein Refseq : NP_063937
MIM : 606784
UniProt ID : P49840
Chromosome Location : 19q13
Function : ATP binding; protein binding; nucleotide binding; transferase activity; glycogen synthase kinase 3 activity; protein kinase A catalytic subunit binding; tau-protein kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
08/12/2020

    Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

    09/18/2019

      This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

      04/10/2019

        the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.

        Q&As (5)

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        In what ways is GSK3A linked to diabetes? 09/27/2021

        GSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.

        Can GSK3A inhibitors have an impact on mood disorders? 11/16/2019

        Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.

        Are there GSK3A modulators being explored for anti-inflammatory therapies? 08/28/2019

        Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.

        How does GSK3A contribute to inflammatory conditions? 04/25/2017

        GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.

        Are there any clinical interventions targeting GSK3A for diabetes management? 04/02/2016

        Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.

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