Recombinant Human GNS Protein, His-tagged

• Cat.No.: GNS-805H
• Product Overview: Recombinant Human GNS(Val37­Leu552) fused with His tag at C-terminal was expressed in HEK293 cells.

Specification

• Description: The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
• Source: HEK293 cells
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Molecular Mass: 59.3 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GNS glucosamine (N-acetyl)-6-sulfatase [ Homo sapiens ]
• Official Symbol: GNS
• Synonyms: GNS; glucosamine (N-acetyl)-6-sulfatase; N-acetylglucosamine-6-sulfatase; N acetylglucosamine 6 sulfatase; Sanfilippo disease IIID; glucosamine-6-sulfatase; G6S; MGC21274
• Gene ID: 2799
• mRNA Refseq: NM_002076
• Protein Refseq: NP_002067
• MIM: 607664
• UniProt ID: P15586