Recombinant Human HACE1 Protein (E2-A909), His tagged

• Cat.No.: HACE1-0421H
• Product Overview: Recombinant Human 6His-TEV-(GG)-HACE1(E2-A909 end) Protein was expressed in E. coli.

Specification

• Description: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: E2-A909
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]
• Official Symbol: HACE1
• Synonyms: HACE1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase HACE1; KIAA1320; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
• Gene ID: 57531
• mRNA Refseq: NM_020771
• Protein Refseq: NP_065822
• MIM: 610876
• UniProt ID: Q8IYU2