Recombinant Human hes family bHLH transcription factor 7, His-tagged

• Cat.No.: HES7-399H
• Product Overview: HES7, 1-230 aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-230 a.a.
• Description: HES7 is a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human HES7 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 27 kDa (253aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMVTRDRA ENRDGPKMLK PLVEKRRRDR INRSLEELRL LLLERTRDQN LRNPKLEKAE ILEFAVGYLR ERSRVEPPAA AAPGVPRSPV QDAEALASCY LSGFRECLLR LAAFAHDASP AARAQLFSAL HGYLRPKPPR PKPVDPRPPA PRPSLDPAAP ALGPALHQRP PVHQGHPSPR CAWSPSLCSP RAGDSGAPAP LTGLLPPPPP PHRQDGAPKA PLPPPPAFWR PWP
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: HES7 hairy and enhancer of split 7 (Drosophila) [ Homo sapiens ]
• Official Symbol: HES7
• Synonyms: HES7; hairy and enhancer of split 7 (Drosophila); transcription factor HES-7; bHLH factor Hes7; bHLHb37; hHes7; class B basic helix-loop-helix protein 37; SCDO4
• Gene ID: 84667
• mRNA Refseq: NM_001165967
• Protein Refseq: NP_001159439
• MIM: 608059
• UniProt ID: Q9BYE0
• Chromosome Location: 17p13.1
• Function: DNA binding; transcription factor binding