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Recombinant Human HNRNPU Protein, GST-tagged

Cat.No. : HNRNPU-4907H
Product Overview : Human HNRNPU full-length ORF (NP_114032.2, 1 a.a. - 825 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 117 kDa
AA Sequence : MSSSPVNVKKLKVSELKEELKKRRL SDKGLKAELMERLQAALDDEEAGGR PAMEPGNGSLDLGGDSAGRSGAGLE QEAAAGGDEEEEEEEEEEEGISALD GDQMELGEENGAAGAADSGPMEEEE AASEDENGDDQGFQEGEDELGDEEE GAGDENGHGEQQPQPPATQQQQPQQ QRGAAKEAAGKSSGPTSLFAVTVAP PGARQGQQQAGGKKKAEGGGGGGRP GAPAAGDGKTEQKGGDKKRGVKRPR EDHGRGYFEYIEENKYSRAKSPQPP VEEEDEHFDDTVVCLDTYNCDLHFK ISRDRLSASSLTMESFAFLWAGGRA SYGVSKGKVCFEMKVTEKIPVRHLY TKDIDIHEVRIGWSLTTSGMLLGEE EFSYGYSLKGIKTCNCETEDYGEKF DENDVITCFANFESDEVELSYAKNG QDLGVAFKISKEVLAGRPLFPHVLC HNCAVEFNFGQKEKPYFPIPEEYTF IQNVPLEDRVRGPKGPEEKKDCEVV MMIGLPGAGKTTWVTKHAAENPGKY NILGTNTIMDKMMVAGFKKQMADTG KLNTLLQRAPQCLGKFIEIAARKKR NFILDQTNVSAAAQRRKMCLFAGFQ RKAVVVCPKDEDYKQRTQKKAEVEG KDLPEHAVLKMKGNFTLPEVAECFD EITYVELQKEEAQKLLEQYKEESKK ALPPEKKQNTGSKKSNKNKSGKNQF NRGGGHRGRGGFNMRGGNFRGGAPG NRGGYNRRGNMPQRGGGGGGSGGIG YPYPRAPVFPGRGSYSNRGNYNRGG MPNRGNYNQNFRGRGNNRGYKNQSQ GYNQWQQGQFWGQKPWSQHYHQGYY
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) [ Homo sapiens ]
Official Symbol : HNRNPU
Synonyms : HNRNPU; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); HNRPU; heterogeneous nuclear ribonucleoprotein U; hnRNPU; SAF A; pp120; p120 nuclear protein; scaffold attachment factor A; SAF-A; U21.1; hnRNP U;
Gene ID : 3192
mRNA Refseq : NM_004501
Protein Refseq : NP_004492
MIM : 602869
UniProt ID : Q00839

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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