| Description : |
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
35.3 kDa |
| AA Sequence : |
MATAQLSHCITIHKASKETVFPSQI TNEHESLKMVKKLFATSISCITYLR GLFPESSYGERHLDDLSLKILREDK KCPGSLHIIRWIQGCFDALEKRYLR MAVLTLYTDPMGSEKVTEMYQFKFK YTKEGATMDFDSHSSSTSFESGTNN EDIKKASVLLIRKLYILMQDLEPLP NNVVLTMKLHYYNAVTPHDYQPLGF KEGVNSHFLLFDKEPINVQVGFVST GFHSMKVKVMTEATKVIDLENNLFR ENSTTEIAHQGLDCDEEEECNDHIQ RMNFVCSQQSSECSRKKRKVSEPVK VFIPNRKTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
