| Description : |
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
121.7 kDa |
| AA Sequence : |
MESTPSFLKGTPTWEKTAPENGIVR QEPGSPPRDGLHHGPLCLGEPAPFW RGVLSTPDSWLPPGFPQGPKDMLPL VEGEGPQNGERKVNWLGSKEGLRWK EAMLTHPLAFCGPACPPRCGPLMPE HSGGHLKSDPVAFRPWHCPFLLETK ILERAPFWVPTCLPPYLVSGLPPEH PCDWPLTPHPWVYSGGQPKVPSAFS LGSKGFYYKDPSIPRLAKEPLAAAE PGLFGLNSGGHLQRAGEAERPSLHQ RDGEMGAGRQQNPCPLFLGQPDTVP WTSWPACPPGLVHTLGNVWAGPGDG NLGYQLGPPATPRCPSPEPPVTQRG CCSSYPPTKGGGLGPCGKCQEGLEG GASGASEPSEEVNKASGPRACPPSH HTKLKKTWLTRHSEQFECPRGCPEV EERPVARLRALKRAGSPEVQGAMGS PAPKRPPDPFPGTAEQGAGGWQEVR DTSIGNKDVDSGQHDEQKGPQDGQA SLQDPGLQDIPCLALPAKLAQCQSC AQAAGEGGGHACHSQQVRRSPLGGE LQQEEDTATNSSSEEGPGSGPDSRL STGLAKHLLSGLGDRLCRLLRRERE ALAWAQREGQGPAVTEDSPGIPRCC SRCHHGLFNTHWRCPRCSHRLCVAC GRVAGTGRAREKAGFQEQSAEECTQ EAGHAACSLMLTQFVSSQALAELST AMHQVWVKFDIRGHCPCQADARVWA PGDAGQQKESTQKTPPTPQPSCNGD THRTKSIKEETPDSAETPAEDRAGR GPLPCPSLCELLASTAVKLCLGHER IHMAFAPVTPALPSDDRITNILDSI IAQVVERKIQEKALGPGLRAGPGLR KGLGLPLSPVRPRLPPPGALLWLQE PQPCPRRGFHLFQEHWRQGQPVLVS GIQRTLQGNLWGTEALGALGGQVQA LSPLGPPQPSSLGSTTFWEGFSWPE LRPKSDEGSVLLLHRALGDEDTSRV ENLAASLPLPEYCALHGKLNLASYL PPGLALRPLEPQLWAAYGVSPHRGH LGTKNLCVEVADLVSILVHADTPLP AWHRAQKDFLSGLDGEGLWSPGSQV STVWHVFRAQDAQRIRRFLQMVQGL VSTVSVTQHFLSPETSALSAQLCHQ GPSLPPDCHLLYAQMDWAVFQAVKV AVGTLQEAKTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
