Recombinant Human HSCB Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: HSCB-5456H
• Product Overview: HSCB MS Standard C13 and N15-labeled recombinant protein (NP_741999) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 27.2 kDa
• AA Sequence: MWRGRAGALLRVWGFWPTGVPRRRP LSCDAASQAGSNYPRCWNCGGPWGP GREDRFFCPQCRALQAPDPTRDYFS LMDCNRSFRVDTAKLQHRYQQLQRL VHPDFFSQRSQTEKDFSEKHSTLVN DAYKTLLAPLSRGLYLLKLHGIEIP ERTDYEMDRQFLIEIMEINEKLAEA ESEAAMKEIESIVKAKQKEFTDNVS SAFEQDDFEEAKEILTKMRYFSNIE EKIKLKKIPLTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: HSCB HscB mitochondrial iron-sulfur cluster cochaperone [ Homo sapiens (human) ]
• Official Symbol: HSCB
• Synonyms: HSCB; HscB iron-sulfur cluster co-chaperone homolog (E. coli); JAC1; HSC20; DNAJC20; dJ366L4.2; iron-sulfur cluster co-chaperone protein HscB, mitochondrial; J-type co-chaperone HSC20; dnaJ homolog subfamily C member 20; DnaJ (Hsp40) homolog, subfamily C, member 20; Jac1
• Gene ID: 150274
• mRNA Refseq: NM_172002
• Protein Refseq: NP_741999
• MIM: 608142
• UniProt ID: Q8IWL3