Recombinant Human ICOS protein
Cat.No. : | ICOS-390H |
Product Overview : | Recombinant Human ICOS(Met 1-Phe 141) was expressed in HEK293. |
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Description : | Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness. |
Source : | HEK293 |
Species : | Human |
Predicted N Terminal : | Glu 21 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Protein length : | Met 1-Phe 141 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 94 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigradeto -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | ICOS inducible T-cell co-stimulator [ Homo sapiens ] |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850; |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; |
Products Types
◆ Recombinant Protein | ||
ICOS-4422H | Recombinant Human ICOS Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOS-827M | Active Recombinant Mouse ICOS protein(Met1-Leu144), rFc-tagged | +Inquiry |
ICOS-055H | Recombinant Human ICOS Protein, His-tagged | +Inquiry |
ICOS-2008R | Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOS-672H | Recombinant Human ICOS Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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