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Recombinant Human ICOS protein, Fc-tagged
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Cat.No. : | ICOS-3244H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human ICOS (Glu21-Phe141) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
Description : | Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Glu21 |
Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 40.2 kDa. The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Glu21-Phe141 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of ICOS-3244H : |
![]() Human ICOS, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Bioactivity-ELISA of ICOS-3244H : |
![]() Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Human ICOS, Fc Tag with a linear range of 0.4-6 ng/mL (QC tested). |
Gene Name : | ICOS |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850 |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
◆ Recombinant Protein
ICOS-827M | Recombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged | +Inquiry |
ICOS-1015R | Recombinant Rhesus ICOS Protein (Met1-Lys140), HlgG1 Fc-tagged | +Inquiry |
ICOS-3729C | Recombinant Chicken ICOS | +Inquiry |
ICOS-2981R | Recombinant Rat ICOS Protein | +Inquiry |
Icos-8799R | Recombinant Rat Icos, Fc tagged | +Inquiry |
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◆ Lysates
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
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