Active Recombinant Mouse Icos, MIgG2a Fc-tagged

• Cat.No.: Icos-1821M
• Product Overview: The extracellular domain of mouse CD278 [ICOS] (NP_059508.2) (Glu21-Leu142) is fused to the N-terminus of the Fc region of mouse IgG2a.

Specification

• Description: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimersand plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
• Source: CHO cells
• Species: Mouse
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 40 KDa (monomer)
• AA Sequence: Glu21-Leu142
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Icos inducible T cell co-stimulator [ Mus musculus ]
• Official Symbol: Icos
• Synonyms: ICOS; inducible T cell co-stimulator; inducible T-cell costimulator; CD28-related protein 1; CD28 and CTLA-4-like protein; inducible T-cell co-stimulator; activation-inducible lymphocyte immunomediatory molecule; H4; CCLP; AILIM; CRP-1; Ly115
• Gene ID: 54167
• mRNA Refseq: NM_017480
• Protein Refseq: NP_059508
• Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
• Function: protein binding