Recombinant Human IDO1 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: IDO1-085H
• Product Overview: IDO1 MS Standard C13 and N15-labeled recombinant protein (NP_002155) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 45.3 kDa
• AA Sequence: MAHAMENSWTISKEYHIDEEVGFAL PNPQENLPDFYNDWMFIAKHLPDLI ESGQLRERVEKLNMLSIDHLTDHKS QRLARLVLGCITMAYVWGKGHGDVR KVLPRNIAVPYCQLSKKLELPPILV YADCVLANWKKKDPNKPLTYENMDV LFSFRDGDCSKGFFLVSLLVEIAAA SAIKVIPTVFKAMQMQERDTLLKAL LEIASCLEKALQVFHQIHDHVNPKA FFSVLRIYLSGWKGNPQLSDGLVYE GFWEDPKEFAGGSAGQSSVFQCFDV LLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGD AGLREAYDACVKALVSLRSYHLQIV TKYILIPASQQPKENKTSEDPSKLE AKGTGGTDLMNFLKTVRSTTEKSLL KEGTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens (human) ]
• Official Symbol: IDO1
• Synonyms: IDO1; indoleamine 2,3-dioxygenase 1; IDO; IDO-1; INDO; indoleamine 2,3-dioxygenase 1; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; EC 1.13.11.52
• Gene ID: 3620
• mRNA Refseq: NM_002164
• Protein Refseq: NP_002155
• MIM: 147435
• UniProt ID: P14902