Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : IKZF1-2552H
Product Overview : IKZF1 MS Standard C13 and N15-labeled recombinant protein (NP_006051) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57.3 kDa
AA Sequence : MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVGKP HKCGYCGRSY KQRSSLEEHK ERCHNYLESM GLPGTLYPVI KEETNHSEMA EDLCKIGSER SLVLDRLASN VAKRKSSMPQ KFLGDKGLSD TPYDSSASYE KENEMMKSHV MDQAINNAIN YLGAESLRPL VQTPPGGSEV VPVISPMYQL HKPLAEGTPR SNHSAQDSAV ENLLLLSKAK LVPSEREASP SNSCQDSTDT ESNNEEQRSG LIYLTNHIAP HARNGLSLKE EHRAYDLLRA ASENSQDALR VVSTSGEQMK VYKCEHCRVL FLDHVMYTIH MGCHGFRDPF ECNMCGYHSQ DRYEFSSHIT RGEHRFHMST RTRPLEQKLI SEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : IKZF1 IKAROS family zinc finger 1 [ Homo sapiens (human) ]
Official Symbol : IKZF1
Synonyms : IKZF1; IKAROS family zinc finger 1 (Ikaros); zinc finger protein, subfamily 1A, 1 (Ikaros), ZNFN1A1; DNA-binding protein Ikaros; hIk 1; Hs.54452; IKAROS; LyF 1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein, subfamily 1A, 1 (Ikaros); IK1; LYF1; hIk-1; PRO0758; ZNFN1A1;
Gene ID : 10320
mRNA Refseq : NM_006060
Protein Refseq : NP_006051
MIM : 603023
UniProt ID : Q13422

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