IL10RA-001H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant human IL10RA (Met1-Asn235) protein without tag was expressed in Spodoptera frugiperda.
Description :
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Source :
Insect cell
Species :
Human
Bio-activity :
Measured by its ability to inhibit IL-10-dependent proliferation of MC/9‑2 mouse mast cells. The ED50 for this effect is 0.05‑0.25 µg/mL in the presence of 2 ng/mL of Recombinant Human IL‑10.
Molecular Mass :
24.4 kDa
N-terminal Sequence Analysis :
His22
Endotoxin :
<0.10 EU per 1 μg of the protein by the LAL method.
Purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage :
Avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer :
Lyophilized from a 0.2 μm filtered solution in PBS.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.