Recombinant Human IL12 Protein
| Cat.No. : | IL12-47H |
| Product Overview : | This recombinant protein contains full length of Human Interleukin 12 without tag was expressed in insect cell. |
- Specification
- Gene Information
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| Description : | This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. |
| Source : | Insect cell |
| Species : | Human |
| Form : | Affinity purified, liquid |
| Molecular Mass : | 64 kDa |
| Purity : | >95% pure by SDS-PAGE |
| Applications : | Suitable for use in ELISA, WB and other immune tests |
| Storage : | Upon receipt, aliquot and store at ≤ - 20 centigrade. Avoid multiple freeze/thaw cycles |
| Storage Buffer : | PBS, pH 7.3 |
| Gene Name : | IL12A interleukin 12A [ Homo sapiens (human) ] |
| Official Symbol : | IL12A |
| Synonyms : | IL12A; interleukin 12A; P35; CLMF; NFSK; NKSF1; IL-12A; interleukin-12 subunit alpha; CLMF p35; IL-12, subunit p35; IL35 subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain |
| Gene ID : | 3592 |
| mRNA Refseq : | NM_000882 |
| Protein Refseq : | NP_000873 |
| MIM : | 161560 |
| UniProt ID : | P29459 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionFluorescence microscopy tracks IL12 internalization and trafficking.
Phosphoproteomics and flow cytometry dissect IL12's signaling and crosstalk.
Flow cytometry and ELISA assess IL12's T cell subset polarization and cytokine profiles.
Reporter gene assays analyze IL12's promoter activity and response elements.
Super-resolution imaging details IL12's cellular distribution and dynamics.
3D cell culture models reveal IL12's effects on tissue microenvironments.
Co-localization studies and co-IP assays identify IL12's binding partners.
Techniques like co-immunoprecipitation reveal IL12 receptor complex assembly.
ChIP-seq helps map IL12-induced gene expression patterns and regulatory regions.
Transgenic models elucidate IL12's roles in immune response regulation.
Customer Reviews (3)
Write a reviewEffective in Th1 cell differentiation. -
High specificity in ELISA. -
Stable under storage. -
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