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Recombinant Human IL12B & IL23A Heterotrimer Protein (Met1-Ser328 & Arg20-Pro189), His-tagged, Biotinylated

Cat.No. : IL23-1037H
Product Overview : Recombinant Human IL12B & IL23A Heterotrimer Protein (NP_002178.2)(Met1-Ser328) & (NP_057668.1)(Arg20-Pro189) was produced by HEK293 Cells expression system. This protein was linked by a polypeptide linker was fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
  • Specification
  • Gene Information
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Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ile 23
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human IL23 complex (IL23A&IL12B) consists 502 amino acids and predicts a molecular mass of 55.8 kDa.
Protein length : Met1-Ser328 & Arg20-Pro189
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : IL12B interleukin 12B [ Homo sapiens (human) ] & IL23A interleukin 23 subunit alpha [ Homo sapiens (human) ]
Official Symbol : IL12B & IL23A
Synonyms : CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B & P19; SGRF; IL-23; IL-23A; IL23P19
Gene ID : 3593 & 51561
mRNA Refseq : NM_002187 & NM_016584
Protein Refseq : NP_002178 & NP_057668
UniProt ID : P29460 & Q9NPF7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Does IL23 expression correlate with disease severity in psoriasis? 05/12/2022

IL23 expression correlates with disease severity in psoriasis.

Does IL23 expression vary between different immune cell types? 06/03/2021

IL23 expression varies among dendritic cells and macrophages.

What are the downstream targets of IL23 signaling? 07/24/2020

IL23 activates STAT3 to modulate downstream targets.

Does IL23 interact with other cytokines in a signaling cascade? 06/07/2019

IL23 interacts with IL-12 to form a signaling cascade.

Is IL23 involved in the activation of STAT3? 04/29/2019

IL23 is involved in the activation of STAT3.

How does IL23 expression change in autoimmune diseases? 10/02/2018

IL23 expression is upregulated in autoimmune diseases like Crohn's.

What is the half-life of IL23 in plasma? 01/14/2018

The half-life of IL23 in plasma is approximately 2 hours.

How does IL23 affect macrophage polarization? 10/25/2017

IL23 induces M1 macrophage polarization.

What is the role of IL23 in Th17 cell differentiation? 03/19/2017

IL23 promotes Th17 cell differentiation by activating STAT3.

How does IL23 contribute to tissue inflammation? 01/27/2016

IL23 contributes to tissue inflammation by activating macrophages.

Customer Reviews (3)

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Reviews
12/17/2021

    High purity levels in CHIP

    12/26/2018

      Effective in T-cell differentiation.

      09/25/2018

        Suitable for signaling studies.

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