Recombinant Human IL1RA protein, GST-tagged

Cat.No. : IL1RA-3697H
Product Overview : Recombinant Human IL1RA protein(1-159 aa), fused to GST tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : GST
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
Protein length : 1-159 aa
AA Sequence : MALETICRPSGRKSSKMQAFRIWDV NQKTFYLRNNQLVAGYLQGPNVNLE EKIDVVPIEPHALFLGIHGGKMCLS CVKSGDETRLQLEAVNITDLSENRK QDKRFAFIRSDSGPTTSFESAACPG WFLCTAMEADQPVSLTNMPDEGVMV TKFYFQEDE
Purity : 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Short-term storage: Store at 2-8°C for (1-2 weeks).
Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
Gene Name : IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]
Official Symbol : IL1RA
Synonyms : IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; P80; IL1R; IL1RA; IL-1R-alpha;
Gene ID : 3554
mRNA Refseq : NM_000877.2
Protein Refseq : NP_000868.1
MIM : 147810
UniProt ID : P14778

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What methodologies can be employed to decipher IL1RA's role in modulating IL-1 receptor complex assembly, particularly regarding structural changes and stoichiometry? 09/12/2022

Methodologies to decipher IL1RA's role in IL-1 receptor complex assembly include structural analyses and stoichiometry assessments.

How does IL1RA's presence impact the cross-talk between IL-1 and other cytokine pathways, and what systems biology approaches can dissect these interactions comprehensively? 05/15/2021

IL1RA's presence influences cross-talk between IL-1 and other cytokine pathways; systems biology approaches dissect interactions.

What structural features of IL1RA enable its competitive inhibition of IL-1 signaling, and how can molecular dynamics simulations elucidate its binding mechanisms? 12/02/2020

IL1RA competitively inhibits IL-1 signaling; molecular dynamics simulations unravel its binding mechanisms.

How does IL1RA's glycosylation profile affect its stability, secretion, and bioactivity, and how can mass spectrometry-based glycoproteomics uncover glycosylation patterns? 10/04/2019

IL1RA's glycosylation affects stability, secretion, and bioactivity; glycoproteomics unveils glycosylation patterns.

In what ways can genome editing techniques shed light on IL1RA gene regulation and potential polymorphisms that might affect its expression levels and function? 07/24/2019

Genome editing techniques reveal IL1RA gene regulation and potential polymorphisms affecting its expression and function.

How does IL1RA's anti-inflammatory potential translate into clinical scenarios, and what methodologies can assess its therapeutic efficacy in various inflammatory diseases? 02/16/2019

IL1RA's anti-inflammatory potential is assessed clinically; methodologies gauge its efficacy in diverse inflammatory diseases.

What innovative strategies, such as targeted delivery systems or bioengineered IL1RA derivatives, offer potential for enhancing the therapeutic impact of IL1RA-based treatments? 09/22/2018

Targeted delivery systems and bioengineered derivatives enhance IL1RA-based treatments' therapeutic potential.

What are the downstream signaling events initiated by IL1RA binding to IL-1 receptors, and how can phosphoproteomics help map the signaling cascade? 01/24/2018

IL1RA binding triggers downstream signaling; phosphoproteomics maps the signaling cascade.

What experimental models, including organoids and in vivo models, provide insights into IL1RA's role in tissue-specific anti-inflammatory responses? 08/12/2017

Organoids and in vivo models reveal IL1RA's role in tissue-specific anti-inflammatory responses.

How does IL1RA's binding affinity to IL-1 receptors vary under different physiological conditions, and how can surface plasmon resonance assays quantify these interactions? 10/09/2016

IL1RA's binding affinity to IL-1 receptors fluctuates with physiological conditions; surface plasmon resonance assays quantify these interactions.

Customer Reviews (3)

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Reviews
09/29/2022

    Effective in cell differentiation.

    11/22/2019

      Suitable for Western blot.

      07/26/2018

        High reproducibility.

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